Cancer is often caused by the "bad luck" of random mutations that arise when cells divide, not family history or environmental causes, US researchers said Thursday. The study in the January 2 edition of the journal Science was led by researchers at Johns Hopkins University and based on a statistical model that includes many types of cancer in a range of human tissues. In the adult cancers they did measure, about two-thirds could be explained by random mutation in genes that encourage tumors to grow, while the remaining one third was due to environmental factors and inherited genes. "This study shows that you can add to your risk of getting cancers by smoking or other poor lifestyle factors," said study author Bert Vogelstein, a professor of oncology at the Johns Hopkins University School of Medicine.
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