Discovery of protein factories may lead to novel agents for the treatment of cancer

For 10 years, Patrick Cramer and his colleagues at Ludwig-Maximilians-Universitaet (LMU) in Munich have probed the structure of RNA polymerase I, a crucial cog in the machinery of all cells. Now they unveil the full three-dimensional conformation of the enzyme - at atomic resolution. Actively growing cells must synthesize large amounts of protein, which in turn requires huge numbers of protein production plants, the so-called ribosomes. Ribosomes themselves consist of proteins mounted on a framework of ribosomal RNA... via Health News from Medical News Today Read More Here..