Detecting ERG gene deletion may be useful for risk stratification in childhood ALL

Results of EORTC trial 58951 suggest that detecting ERG gene deletion at diagnosis of childhood B-cell precursor (BCP) acute lymphoblastic leukemia (ALL) would be useful for risk stratification. The study, published in Leukemia showed that patients with the ERG gene deletion had a very good outcome with an 8-year event-free survival of 86.4% and an overall survival of 95.6%. ALL is the most common childhood malignancy, but it is characterized by a number of recurring genetic alterations. These alterations, each with a specific gene expression profile, can influence response to treatment... via Health News from Medical News Today Read More Here..