Melanoma patients with BRAF mutation usually have a positive response to treatment with BRAF inhibitors, but nearly all of those patients develop resistance to the drugs and experience disease progression. Now, a new preclinical study published online ahead of print in the ia/i from Penn Medicine researchers found that in many cases the root of the resistance may lie in a never-before-seen autophagy mechanism induced by the BRAF inhibitors vermurafenib and ...Wednesday, 26 February 2014
Resistance to BRAF Drugs In Melanoma may be Overcome by Blocking Autophagy With Malaria Drug
Melanoma patients with BRAF mutation usually have a positive response to treatment with BRAF inhibitors, but nearly all of those patients develop resistance to the drugs and experience disease progression. Now, a new preclinical study published online ahead of print in the ia/i from Penn Medicine researchers found that in many cases the root of the resistance may lie in a never-before-seen autophagy mechanism induced by the BRAF inhibitors vermurafenib and ...
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