It has been suggested that antibodies against prion protein might have therapeutic value. However, a study in this week's Nature shows that many antiprion antibodies cause neurotoxicity and also reveals the mechanism underlying these observations. The prion protein - which in a misfolded form is associated with neurotoxic effects such as those seen in Creutzfeldt-Jakob disease - contains a globular domain and a flexible tail. Aguzzi and colleagues show that antibodies against the globular domain cause neurotoxicity in mice and cerebellar cultured slices...
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