New research shows how premalignant cells can respond to an activated RAS gene by entering a quiescent state, called senescence and halt cancer growth. CSHL Professor Nicholas Tonks and Benoit Boivin, now a University of Montreal Assistant Professor, co-led a team that traced the process in exquisite detail. They began by confirming that activation of mutant, oncogenic H-RAS, one of the human RAS oncogene variants, spurs cells to generate hydrogen peroxide ...
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