A genetic disease associated with enhanced susceptibility to infection, autoimmunity, and decreased antibody production is common variable immune deficiency (CVID). Mutations in the tumor necrosis factor receptor superfamily member iTACI/i, are associated with CVID and autoimmunity development. Interestingly, autoimmunity develops in CVID patients with only one mutated copy of iTACI/i, and CVID patients with two mutated iTACI/i alleles do not develop autoimmunity. ...
via Medindia Health News
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