Thursday, 6 October 2016

Sons born with fertility treatment 'inherit problems'

Boys born to fathers who needed help conceiving grow up to have poorer sperm quality than peers conceived without help, a study has found. via BBC News - Health Read More Here..

Teenagers' brain connections 'make them learn differently'

Teenagers are better at learning from their experiences than adults, according to a American study of teen brains in the journal Neuron. via BBC News - Health Read More Here..

Teenagers 'checking mobile phones in night'

Almost half (45%) of young people are checking their mobile phones after they have gone to bed, a poll suggests. via BBC News - Health Read More Here..

Wasted money?

Nick Triggle answers a reader's question on why the NHS continues to fund homeopathy in the UK. via BBC News - Health Read More Here..

Wednesday, 5 October 2016

Should I Drink Turmeric Tea?

Should I Drink Turmeric Tea? Blog Post

The same golden-hued spice added to curries and in mustard is now making waves as turmeric tea. Deservedly so: turmeric seems to boast a slew of benefits.

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Why men should ignore Ben Stiller’s call for cancer test

The actor says a prostate cancer blood test saved his life, but that doesn't mean others should get tested, says Clare Wilson via New Scientist - Health Read More Here..

Limit to human life may be 115 (ish)

Our life spans appear to be limited to about 115 years, according to US scientists. via BBC News - Health Read More Here..

Diabetes Drug for Addiction Treatment

A relatively new class of drugs, glucagon-like peptide-1 (GLP-1) receptor agonists, have had much success in the treatment of type 2 diabetes. Now, these drugs may offer support in the treatment of addiction and drug abuse.

A new study, published in Translational Psychiatry, reports that GLP-1 receptors may be a target for treating drug abuse. The study was conducted in mice, but it calls attention to previous reports with similar findings.

Dopamine is essential to reward pathways that influence drug abuse and addiction. Endocannabinoids and arachidonic acid, which are also naturally present in the brain, affect the function of dopamine transporters. Activation of GLP-1 receptors reduces arachidonic acid in areas of the brain that are associated with reward; dopamine levels, in turn, reduce. In the current study, the long-lasting GLP-1 receptor agonist, exenatide, abolished cocaine-induced increases in dopamine levels.

GLP-1 is normally found in the gut and influences satiety signaling. In part, GLP-1 agonists, which mimic the activity of naturally-occurring GLP-1, regulate glucose homeostasis in type 2 diabetes by promoting a feeling of fullness. These drugs have been shown to aid in weight loss in patients with type 2 diabetes. These effects might also be due to the reduction in the rewarding effects of food, owing to GLP-1 action in regulating dopamine transporter activity and reducing reward related to food intake.

Both illicit drugs and palatable foods activate reward pathways in the brain. Therefore, pharmacologic modulation of these central nervous system circuits holds promise for reducing unwanted or abusive behaviors. The role of naturally occurring GLP-1 in affecting reward is unknown. The beneficial effects of GLP-1 agonist activity are now believed to extend not just to food, but alcohol and to psychostimulants, such as cocaine and amphetamine.

Several recent studies have highlighted the mechanism by which GLP-1 agonists influence reward-inducing behaviors in the central nervous system. While the place in therapy is not clearly defined, these findings could expand the therapeutic potential of this entire class of drugs.

References

Harasta AE, Power JM, von Jonquieres G, et al. Septal glucagon-like peptide 1 receptor expression determines suppression of cocaine-induced behavior (2015) Neuropsychopharmacology, 40(8):1969-78. PMID: 25669605

Reddy IA, Pino JA, Weikop P, et al. Glucagon-like peptide-1 receptor activation regulates cocaine actions and dopamine homeostasis in the lateral septum by decreasing arachidonic acid levels (2016) Transl Psychiatry, 6:e809. PMID: 27187231

Richards JE, Anderberg RH, Goteson, et al. Activation of the GLP-1 receptors in the nucleus of the solitary tract reduces food reward behavior and targets the mesolimbic system (2015) PLoS One, 110(3):e0119034. PMID: 25793511

Sirohi S, Schurdak JD, Seeley RJ, et al. Contral peripheral glucagon-like peptide-1 receptor signaling differentially regulate addictive behaviors (2016) Physiol Behav, 161:140-4. PMID: 27072507

Skibicka KP. The central GLP-1: implications for food and drug reward (2013) Front Neurosci 7:181. PMID: 24133407

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Don’t let rift between generations spark a toxic era of ageism

We need to restore peace between young and old as resentment over healthcare, jobs and pensions fuels ageism. How can we do it, wonders Michael North via New Scientist - Health Read More Here..

MEPs to vote on ban of bisphenol in food packaging

British Breast Cancer charity welcomes proposal

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Mental health services for children inadequate

Poll finds 1 in 10 nurses describe it this way

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Investing in early childhood development essential to helping more children and communities thrive, new Lancet Series finds

An estimated 43 percent—249 million—of children under five in low-and middle-income countries (LMICs) are at an elevated risk of poor development due to extreme poverty and stunting, according to findings from The Lancet’s new Series, Advancing Early Childhood Development: from Science to Scale. via WHO news Read More Here..

Junior doctors' contract should be scrapped, says senior doctor

President of Royal College says contract is ‘damaged goods’

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CCGs struggling to meet cancer targets

Review shows 8 in 10 areas need to improve

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Activity trackers do not improve health; study suggests

Use of pedometers slackens within first six months

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Does the contraceptive pill cause depression?

A study linking the contraceptive pill with depression is met with relief, frustration and debate. via BBC News - Health Read More Here..

Taste for high-fat food 'in our genes'

Some people are genetically wired to prefer the taste of fatty foods, putting them at increased risk of obesity, according to researchers. via BBC News - Health Read More Here..

Tuesday, 4 October 2016

“I’ll Do It Later” – Brain Connectivity Predicts Procrastination

Procrastination — we are all guilty of it. Irrationally delaying a task in day-to-day life can have minor effects, such as lost sleep from staying up late to meet a deadline, but it can also be detrimental. From a health perspective, waiting to go to the doctor until an illness becomes severe could be fatal. In the financial domain, procrastinating on taxes costs people hundreds of dollars per year in overpayments, and failing to start saving early for retirement can end up costing thousands of dollars. So why do we procrastinate, even though we know it is bad for us? There is a common perception that procrastination is associated with laziness or lack of motivation, but a recent fMRI study suggests something else.

A recent study published in Personality and Individual Differences by Wu and colleagues provides some insight into the neural underpinnings of procrastination by looking at a specific type of brain connectivity, resting state functional connectivity (rsFC), and investigating how this relates to individual levels of procrastination. This approach looks at how different regions of the brain are functionally connected, as opposed to anatomically (structurally) connected. When the brain is at “rest”, there is still some activity going on; it is always spontaneously firing at low-frequency fluctuations. Recent research has shown that there are distinct brain networks that fire together at rest, and these patterns have been linked to variations in cognitive abilities and behaviors.

The researchers hypothesized that procrastination is a result of failure in self-regulation, and thus brain regions involving impulsivity control and self-monitoring may have less functional connectivity in individuals who procrastinate more. They used measures of trait procrastination and self-control to assess procrastination tendencies and collected resting state fMRI data during which participants were instructed to lie quietly in the scanner, close their eyes, and let their mind wander for about 6 minutes. After careful analysis, Wu and colleagues were able to confirm that the functional connectivity between the hypothesized brain regions were indeed related to procrastination behavior. The circuit between the ventromedial prefrontal cortex, an area associated with value comparison, and the dorsolateral prefrontal cortex, a region involved in the control of behavior, was found to have reduced connectivity in high procrastinators. Similarly, the connectivity between the dorsal anterior cingulate cortex, involved in cognitive control, and the caudate, a reward processing area of the brain, was also reduced in severe procrastinators. Finally, the researchers evaluated connectivity within the ventrolateral prefrontal cortex, an area responsible for behavioral inhibition, and found that this was reduced in heavy procrastinators as well.

When they put everything together, as they expected, the behavioral measure of self-control was the best predictor of procrastination tendencies, but the neural functional connectivity was actually able to add significant additional predictive power on top of what self-control could predict by itself. This suggests that there is something unique about the neural connectivity that is able to predict procrastination beyond the self- control that is measured in the lab. The reduced functional connectivity in high procrastinators observed in regions of their brains suggest that procrastination is related to other factors linked to self-control, such as impulse control inability and optimal weighting of value options, something that has only been speculated by researchers before.

So, how does this information help researchers figure out ways to help people reduce procrastination? Identifying that procrastination is associated with a lack of self-control and impulsivity provides a good starting point for interventions that may reduce that behavior. A review by Piers Steel at University of Calgary suggests that procrastination might be reduced by increasing one’s confidence about completing a task, reducing distractions, fostering automaticity by creating habits, and setting daily goals. There has also been a recent interest in internet-based cognitive behavioral therapy. Rozental and colleagues at Stockholm University created an online based 8-week treatment program with different modules designed to reduce procrastination, with topics such as goal-setting, time management, and motivation. In a study of 150 participants who all scored extremely high (top 25%) on an index of procrastination behaviors, they found that internet-based cognitive behavior therapy was able to substantially improve self-report difficulties with procrastination in participants who completed the modules in comparison to control participants who did not complete the treatment, demonstrating that online training can indeed be effective for even the worst procrastinators.

One thing is for sure: the recognition of procrastination as a cognitive deficit is increasing. All of this work provides a promising start for awareness and treatments for even the most severe procrastinators.

References

  1. Steel, P. The nature of procrastination: a meta-analytic and theoretical review of quintessential self-regulatory failure. Psychol. Bull. 133, 65–94 (2007). DOI: 10.1037/0033-2909.133.1.65
  1. Wu, Y., Li, L., Yuan, B. & Tian, X. Individual differences in resting-state functional connectivity predict procrastination. Pers. Individ. Dif. 95, 62–67 (2016). DOI: 10.1016/j.paid.2016.02.016
  1. Rozental, A., Forsell, E., Svensson, A., Andersson, G. & Carlbring, P. Internet-Based Cognitive Behavior Therapy for Procrastination: A Randomized Controlled Trial. JMIR Res. Protoc. 83, 808–824 (2015). DOI: 10.1037/ccp0000023

Image via Comfreak / Pixabay.

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Your boobs start to eat themselves after breastfeeding is over

A molecular switch has been identified that prompts cells inside the breasts to transform from milk secretors to cellular eaters that gobble up dying neighbours via New Scientist - Health Read More Here..

Scan suspected stroke patients within 1 hour, says RCP

Royal College of Physicians launches new guidance

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Royal College launches cosmetic surgery advice

Surgeons warns of ‘aggressive marketing’

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42% of British doctors plan to move abroad, study shows

Stress, staff shortages and paperwork cited as factors

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Medical training places to increase by 25%

Doctors say this may not be enough

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Lemons and limeys

James Lind is remembered as the man who helped to conquer a killer disease but why did the Royal Navy take nearly 50 years to act on his findings? via BBC News - Health Read More Here..

First new cancer drug introduced under Cancer Drugs Fund

Osimertinib approved for some patients with lung cancer

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Dying woman picks road trip over chemotherapy

When Norma Bauerschmidt was diagnosed with terminal cancer, she immediately refused treatment, opting to spend her final days on an incredible road trip. via BBC News - Health Read More Here..

Cosmetic surgery check-list for patients

The Royal College of Surgeons is offering patients seeking cosmetic surgery practical advice about how to pick the right hospital and doctor. via BBC News - Health Read More Here..

Student doctor numbers to rise by 25%

The number of medical school places will increase by 25% in 2018 as ministers unveil plans to make the NHS in England "self-sufficient" in training doctors. via BBC News - Health Read More Here..

Urine test for CJD 'a possibility'

UK scientists believe urine could be used for a quick and simple way to test for CJD or "human mad cow disease". via BBC News - Health Read More Here..

Torn at birth

The problem of women being torn during childbirth has for years been exacerbated by improper care and an unwillingness to speak about the issue, experts say. Two women want to change this. via BBC News - Health Read More Here..

The literal life saver

Family and former colleagues reflect on the legacy of Professor Frank Pantridge, the inventor of the portable defibrillator. via BBC News - Health Read More Here..

Monday, 3 October 2016

6 Sensational Cheese Toasts to Pair with Everything

6 Sensational Cheese Toasts to Pair with Everything Blog Post

Don't worry, good ol' grilled cheese, we still love you. But sometimes we want to shake things up a bit. Welcome cheese toast, aka an open-faced grilled cheese or tartine. No need for a frying pan or spatula-cheese toasts can be thrown together with whatever you have in the fridge or pantry.

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E-cigarette 'shoots fireball' on Universal Studios Hogwarts ride

Orlando police say that a 14-year-old girl suffered burns on a Harry Potter ride when a passenger's electronic cigarette exploded. via BBC News - Health Read More Here..

Men are more violent when there are more women around

Contrary to conventional wisdom, a surplus of men in a society doesn’t equal more violence – in fact, the more men, the better-behaved they become via New Scientist - Health Read More Here..

High indoor temperatures exacerbate COPD symptoms

Targeted interventions required, researchers say

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Black Monday: Polish women strike against abortion ban

Some businesses in Poland close for the day as thousands of women go on strike to protest against proposals for a total ban on abortion. via BBC News - Health Read More Here..

The no-hunger diet

Article Oct 3, 2016

Conquer your cravings, feel full – and lose weight for good!

via Healthy Eating Read More..

Nobel Prize for medicine goes to Japanese cell biologist

Yoshinori Ohsumi wins award for work on autophagy

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Johnson seeks to calm scientists’ Brexit fears
Doctors bear burden of Government’s financial failure
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English doctors unlikely to repay student loans
Public awareness of the NHS Constitution grows
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Medicine Nobel Prize goes to discovery of how our cells recycle

Yoshinori Ohsumi has won 2016's Nobel Prize in Physiology or Medicine for his 'discoveries of mechanisms for autophagy' - or how our cells recyle their contents via New Scientist - Health Read More Here..

Online pharmacies undermine bid to curb antibiotic resistance

RCGP calls for adherence to GMC and NICE guidelines

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Yoshinori Ohsumi gets Nobel medicine prize

The 2016 Nobel Prize for physiology or medicine goes to Yoshinori Ohsumi for discoveries about autophagy - how the body breaks down and recycles cellular components. via BBC News - Health Read More Here..

Royal College of Physicians launches annual consultants’ census

Data will help College ‘push for funding’ for additional posts

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Financial boost for child mental health in Scotland

Project extended to include youngest patients

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Mistake led a man to lose a foot

On average, 185 operations were carried out every week in the UK in 2014-15 to amputate the limbs of people with complications linked to diabetes. via BBC News - Health Read More Here..

Animal TB threatens human health say vets and doctors

Animal tuberculosis, which is spread through contaminated food, is a greater threat to human health than previously realised, leading doctors and vets warn. via BBC News - Health Read More Here..

One in six young people eat fast food 'twice a day'

One in six young people eat fast food twice a day, according to a survey of the nation's eating habits. via BBC News - Health Read More Here..

Cancer clusters at nuclear sites 'not linked to radiation'

An investigation into clusters of cancer cases around Sellafield and Dounreay nuclear sites finds they were very unlikely to have been caused by radiation exposure. via BBC News - Health Read More Here..

Best and Worst of Neuroscience and Neurology – August 2016

This article summarizes some interesting publications that came out in August. As usual, there were many interesting developments, both in fundamental neuroscience and neurology, and in practical aspects of dealing with and treating brain-related diseases and disorders.

On August 20, the scientific community marked the birthday of Roger Sperry. Prof. Sperry received the 1981 Nobel Prize for Medicine and Physiology for his works on “split-brain” patients. In these patients, the corpus callosum connecting two brain hemispheres is severed. The works of Roger Sperry helped to establish that our two brain hemispheres do have different functions and often work independently.

THE BEST

Brain maintains representation of amputated hand decades later

It was traditionally assumed that after amputation of a hand or a finger the part of the brain representing it becomes “overwritten” due to the absence of input signals. New data demonstrate that this view is not correct and brain retains the picture of missing limb even several decade later. The findings might prove useful in creating neuroprosthetics – artificial limbs controlled directly by brain signals.

New blood test predicts the likelihood of developing Alzheimer’s disease in the future

Although early Alzheimer’s disease often manifests itself as a mild memory impairment, only some of patients with memory impairment will eventually develop this condition. New blood test developed by British scientists allows to predict the likelihood of developing the Alzheimer’s in the next few years in patients with mild memory problems. The test would help to identify vulnerable patients and advise them early on the course of action to prevent or delay the disease progression.

Parkinson’s disease spreads via intercellular nanotubes

Like most other neurodegenerative diseases, Parkinson’s disease is linked to formation and spread of protein aggregates, alpha-synuclein in the case of this condition. However, not much is known about the mechanisms responsible for the transfer of protein aggregates between the neural cells in brain. This month, researchers reported that alpha-synuclein aggregates can migrate from one cell to another along tunnelling nanotubes. The findings represent a serious breakthrough in understanding Parkinson’s disease and point to some new potentially useful therapeutic targets.

Lead causes oxidative stress in neural stem cells

Environmental exposure to lead is known to cause neurodevelopmental problems, particularly at early stages of life. The molecular mechanisms behind this effect remained unclear, however. Now scientists have found that lead induces oxidative stress in neural stem cells. Specifically, proteins SPP1 and NRF2 were found to be involved in this process. Both proteins are involved in cognitive development.

Genetic reprogramming can convert connective tissue cells into neurons

Genetic reprogramming of mature cells to create pluripotent stem cells was discovered 10 years ago. A number of improved technics for cellular reprogramming was invented since then. A novel revolutionary technique called CRISPR was recently used to convert the cells of connective tissue into neurons. The discovery may pave the way to model neurological disorders and develop cell therapy.

 

THE WORST

Stopping exercise at older age leads to decreased cerebral blood flow

The fact that fitness level drops quite quickly after stopping exercise is well known, but the changes in brain caused by termination of the regular exercise routine are not well studied. In a new research, scientists asked well trained senior athletes aged 50-80 years to stop exercising for 10 days, and then studied their cerebral blood flow. It turned out that all athletes experienced significantly decreased level of resting blood flow in a number of key areas of brain. Importantly, the blood flow was decreased in hippocampus, a part of brain crucial for learning and memory. Researchers believe that stopping exercise at older age may trigger the processes connected to the development of dementia and other neurodegenerative conditions.

Larger brain, not different brain structure, differentiates us from primates

For a long time, scientists believed that our remarkable cognitive abilities are linked to the enlarged prefrontal cortex region of the brain. As the new article published this month shows, this idea was wrong. In both humans and non-human primates, the prefrontal cortex occupies 8% of the brain. Human brain, however, is much bigger and contains 16 billion cortical neurons, while other higher primates have only 6-9 billion of these cells. Apparently, this increased number of neurons, rather than larger prefrontal cortex, is behind our enhanced cognitive abilities.

Calcium supplements increase risk of dementia in women with history of stroke

Osteoporosis is a common problem in elderly women, and calcium supplementation is usually recommended to manage this condition. It turned out, however, that taking calcium supplements is not as safe as it was believed. Women with cerebrovascular diseases such as stroke and white matter lesions are at much higher risk of developing dementia when they regularly take calcium supplements. The risk is 7 times higher among women with a history of stroke who take supplements compared to women with a history of stroke who don’t supplement their diet with calcium. The molecular mechanism behind this phenomenon remains unclear.

Drugs for epilepsy may cause psychotic disorders

People with epilepsy are known to be prone to psychiatric disorders, but it appears that the part of problem is the very drug used to control epileptic seizures. New study revealed that in one out of seven epilepsy patients, the psychiatric disorders can be attributed to the use of this drugs. Women and people with temporal lobe epilepsy are particularly vulnerable to this side effect.

Better education of clinicians needed to avoid misdiagnosis of multiple sclerosis

Due to its rather unspecific manifestations and the lack of reliable biomarkers, multiple sclerosis (MS) can be a challenging condition to diagnose correctly. New study suggests that numerous patients misdiagnosed with other conditions received potentially harmful treatment for a disease they didn’t have. Moreover, the study also shows that in most cases the misdiagnoses were linked to not following the existing diagnostic guidelines and criteria correctly. Better education of clinicians is required to avoid misdiagnosis of MS and recognising patients who were diagnosed incorrectly.

 

References:

Sanne Kikkert, James Kolasinski, Saad Jbabdi, Irene Tracey, Christian F Beckmann, Heidi Johansen-Berg, Tamar R Makin. Revealing the neural fingerprints of a missing hand. eLife, 2016; 5 DOI: 10.7554/eLife.15292

Svetlana Hakobyan, Katharine Harding, Mohammed Aiyaz, Abdul Hye, Richard Dobson, Alison Baird, Benjamine Liu, Claire Louise Harris, Simon Lovestone, Bryan Paul Morgan. Complement Biomarkers as Predictors of Disease Progression in Alzheimer’s Disease. Journal of Alzheimer’s Disease, 2016; 1 DOI: 10.3233/JAD-160420

Saïda Abounit et al. Tunneling nanotubes spread fibrillar ?-synuclein by intercellular trafficking of lysosomes. The EMBO Journal, 2016 DOI: 10.15252/embj.201593411

Quan Lu, David C. Christiani, Robert O. Wright, Tomas R. Guilarte, Kirstie Stanfield, Li Su, Yongyue Wei, Rory Kirchner, Zhaoxi Wang, Hae-Ryung Park, Peter J. Wagner. In Vitro Effects of Lead on Gene Expression in Neural Stem Cells and Associations between Upregulated Genes and Cognitive Scores in Children. Environmental Health Perspectives, 2016; DOI: 10.1289/EHP265

Joshua B. Black, Andrew F. Adler, Hong-Gang Wang, Anthony M. D’Ippolito, Hunter A. Hutchinson, Timothy E. Reddy, Geoffrey S. Pitt, Kam W. Leong, Charles A. Gersbach. Targeted Epigenetic Remodeling of Endogenous Loci by CRISPR/Cas9-Based Transcriptional Activators Directly Converts Fibroblasts to Neuronal Cells. Cell Stem Cell, 2016; DOI: 10.1016/j.stem.2016.07.001

Alfonso J. Alfini, Lauren R. Weiss, Brooks P. Leitner, Theresa J. Smith, James M. Hagberg, J. Carson Smith. Hippocampal and Cerebral Blood Flow after Exercise Cessation in Master Athletes. Frontiers in Aging Neuroscience, 2016; 8 DOI: 10.3389/fnagi.2016.00184

Mariana Gabi, Kleber Neves, Carolinne Masseron, Pedro F. M. Ribeiro, Lissa Ventura-Antunes, Laila Torres, Bruno Mota, Jon H. Kaas, Suzana Herculano-Houzel. No relative expansion of the number of prefrontal neurons in primate and human evolution. Proceedings of the National Academy of Sciences, 2016; 201610178 DOI: 10.1073/pnas.1610178113

Jürgen Kern, MD, PhD et al. Calcium supplementation and risk of dementia in women with cerebrovascular disease. Neurology, August 2016 DOI: 10.1212/WNL.0000000000003111

Ziyi Chen, Ana Lusicic, Terence J. O’Brien, Dennis Velakoulis, Sophia J. Adams, Patrick Kwan. Psychotic disorders induced by antiepileptic drugs in people with epilepsy. Brain, 2016; aww196 DOI: 10.1093/brain/aww196

Andrew J. Solomon, Dennis N. Bourdette, Anne H. Cross, Angela Applebee, Philip M. Skidd, Diantha B. Howard, Rebecca I. Spain, Michelle H. Cameron, Edward Kim, Michele K. Mass, Vijayshree Yadav, Ruth H. Whitham, Erin E. Longbrake, Robert T. Naismith, Gregory F. Wu, Becky J. Parks, Dean M. Wingerchuk, Brian L. Rabin, Michel Toledano, W. Oliver Tobin, Orhun H. Kantarci, Jonathan L. Carter, B. Mark Keegan, Brian G. Weinshenker. The contemporary spectrum of multiple sclerosis misdiagnosis. Neurology, 2016; 10.1212/WNL.0000000000003152 DOI: 10.1212/WNL.0000000000003152

Image via skeeze / Pixabay.

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Saturday, 1 October 2016

Brain-eating amoebas hunt brain chemical before they kill you

A deadly amoeba that can infect swimmers seems to be attracted to a common brain chemical – a discovery that could lead to new treatments via New Scientist - Health Read More Here..

The truth about porn: why masturbation won’t kill your sex life

Has online pornography created a generation of impotent young men with a dangerous addiction to extreme images? Clare Wilson investigates via New Scientist - Health Read More Here..