The highly conserved molecular chaperone heat-shock protein 90 (HSP90), long known for its ability to help organisms successfully adapt to environmentally stressful conditions, also enables estrogen receptor-positive (ER+) breast cancers to develop resistance to hormonal therapy. This HSP90-mediated evolutionary mechanism of drug resistance, reported by Whitehead Institute scientists in this week''s online edition of the iProceedings of the National Academy ...
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