Bottom Line: Young adults and children who start antidepressant therapy at high doses, rather than the prescribed doses, appear to be at greater risk for suicidal behavior during the first 90 days of treatment. Author: Matthew Miller, M.D., Sc.D., of the Harvard School of Public Health, Boston, and colleagues. Background: A previous meta-analysis by the U.S. Food and Drug Administration (FDA) of antidepressant trials suggested that ...
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