A new compound with more than two orders of magnitude higher binding affinity to the chemokine receptor CXCR4 and greatly improved anti-HIV activity results from minimal modification of a synthetic peptide with anti-HIV activity, researchers from Munich and Naples have shown. This could be a step toward the design of new, more effective drugs against AIDS, inflammatory diseases, and some forms of cancer. Different strains of HIV-1 use either the chemokine ...
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