A novel approach to probe temperature in living cells is reported in this week's Nature. The 'nanothermometer' is based on diamond nanocrystals and can accurately measure very small temperature variations at high spatial resolution. Potential applications include temperature-induced control of gene expression, and the cell-selective treatment of diseases. The nanoscale thermometry technique developed by Mikhail Lukin and co-workers uses quantum manipulation of nitrogen vacancy (NV) colour centres in diamond nanocrystals...
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Wednesday, 31 July 2013
How antiprion antibodies cause neurodegeneration
It has been suggested that antibodies against prion protein might have therapeutic value. However, a study in this week's Nature shows that many antiprion antibodies cause neurotoxicity and also reveals the mechanism underlying these observations. The prion protein - which in a misfolded form is associated with neurotoxic effects such as those seen in Creutzfeldt-Jakob disease - contains a globular domain and a flexible tail. Aguzzi and colleagues show that antibodies against the globular domain cause neurotoxicity in mice and cerebellar cultured slices...
via Health News from Medical News Today Read More Here..
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