Scores of mutations that destroy gene function and are found at unusually high frequencies have been unearthed via extensive sequencing of DNA from thousands of individuals in Finland. Among these are two mutations in a gene called LPA that may reduce a person's risk of heart disease. These findings are an exciting proof-of-concept for a new "genotype first" approach to identifying rare genetic variants associated with, or protecting from, disease followed by extensive ...Saturday 2 August 2014
Protective Factor for Heart Disease Uncovered by Innovative 'Genotype First' Approach
Scores of mutations that destroy gene function and are found at unusually high frequencies have been unearthed via extensive sequencing of DNA from thousands of individuals in Finland. Among these are two mutations in a gene called LPA that may reduce a person's risk of heart disease. These findings are an exciting proof-of-concept for a new "genotype first" approach to identifying rare genetic variants associated with, or protecting from, disease followed by extensive ...
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