Wednesday 2 April 2014

Enhancers Control Potentially Dangerous Hypermutation to Antibody Genes

For decades, biologists were fascinated as how B lymphocytes are able to direct mutations to their antibody genes to produce millions of different antibodies. A new study publishing in the Open Access journal iPLOS Biology/i on April 1 by Buerstedde and colleagues shows that this process of programed, spatially targeted genome mutation (aka. somatic hypermutation) is controlled by nearby transcription regulatory sequences called enhancers. Enhancers are usually ...

via Medindia Health News More READ

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