Wednesday, 11 July 2012

First Evidence For Targeting Of Pol I As New Approach To Cancer Therapy



Cylene Pharmaceuticals has announced that research collaborators at the Peter MacCallum Cancer Centre (Peter Mac) in Melbourne, Australia have established, for the first time, that RNA Polymerase I (Pol I) activity is essential for cancer cell survival and that its inhibition selectively activates p53 to kill tumors. Published in Cancer Cell, the findings show that Cylene's Pol I inhibitor, CX-5461, selectively destroys cancer by activating p53 in malignant but not in normal cells...



via Health News from Medical News Today Read More Here..

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